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ea0089b3 | Basic Science | NANETS2022

Development of a Novel Anti-SSTR Bispecific T-Cell Engager (BiTE)-like Molecule for the Treatment of Neuroendocrine Tumors

Pelle Eleonora , Cives Mauro , Medina Elliot , Mason Charlotte C. , Snedal Sebastian A. , Bustos-Perez Xiomar E. , Tordesillas Leticia , Gomez Fontela Miguel , Marques Rossetti Renata A. , Maiorano Gabriele , Luca Vince , Hwu Patrick , Abate-Daga Daniel , Strosberg Jonathan

Background: Well-differentiated neuroendocrine tumors (NETs) are characterized by the overexpression of somatostatin receptors (SSTRs). To efficiently engage and activate tumor infiltrating lymphocytes against NET cells, we designed a novel bispecific T-cells engager (BiTE) composed of 2 molecules of somatostatin-14 (SST14), the hormone that physiologically binds SSTRs, linked with a single chain variable fragment (scFV)-based anti-CD3.Methods: The optim...

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Development of a Novel Anti-SSTR Bispecific T-Cell Engager (BiTE)-like Molecule for the Treatment of Neuroendocrine Tumors

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